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Sunday, 30 October 2022

Neurological disorders notes

 

Patient's Guide to Brain and Other Neurological Disorders

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A wide range of disorders can affect the brain, spinal cord, and nerves throughout the body.

The nervous system, consisting of the brain, spinal cord, and nerves, is essentially the body's control center. It extends from our head to the tips (nerves) of our fingers and toes.

 

A properly functioning nervous system allows you to function on all levels: walking, speaking, breathing, swallowing. Many of these features are automatic and don't require you to think about them. But the same system makes us think deeply, thanks to the complex organs at the heart of it all.

 

“The brain is amazingly complex. The brain is made up of about 86 billion nerve cells, and there are more than a trillion connections between brains and nerve cells throughout the body, she says.

 

However, problems with the nervous system can have serious and even debilitating effects. In some cases, neuropathy can be fatal. According to the American Brain Foundation, brain and nerve disorders affect about 1 in 6 people and cost more than $1 trillion to treat each year. Given the complexity of the brain and the rest of the nervous system, it's no surprise that so many things go wrong. In fact, the National Institute of Neurological Disorders and Stroke supports research on more than 600 neurological disorders.

 

"Broadly, neurological and brain disorders were known as diseases with no real cure," says Benisch. “Brain disorders can be very complicated and many people think there are many things that cannot be treated, but there are many treatments.

Multiple sclerosis (MS) is a disease of the central nervous system in which the body's immune system attacks myelin (nerve tissue). This interrupts neurotransmission between the brain and body. There is a cure for this autoimmune disease, but no cure.

 

Other autoimmune diseases of the brain include:

 

Autoimmune encephalitis.

Autoimmune-related epilepsy.

Hashimoto Encephalopathy

Autism and Neurodevelopmental Disorders

 

Autism Spectrum Disorders are developmental disorders that affect an individual's ability to communicate and interact with others. The disorder can be diagnosed at any age, but symptoms usually appear within the first two years of life.

 

An estimated 1 in 59 children has autism, according to the Centers for Disease Control and Prevention. Autism is characterized by social clumsiness, poor verbal and nonverbal communication, repetitive behaviors, obsessions and habits. The cause is unknown, but genetic and environmental factors are suspected.

 

Other types of neurodevelopmental disorders include hypoxic/ischemic encephalopathy (brain damage caused by lack of oxygen in the brain of the newborn), cerebral palsy, developmental disorders, and attention deficit hyperactivity disorder or ADHD. will be Depending on the severity of the case, drug and behavioral therapy can help, especially if the disease is detected early.

 

Dementia:

 

There are many different types of dementia, including frontotemporal dementia, dementia with Lewy bodies  It is a disease that is The exact cause is unknown, but factors such as aging, genetics, and lifestyle all contribute to dementia.

 

Symptoms of dementia include progressive loss of cognitive and functional abilities, leading to loss of independence. There is currently no effective treatment, but there is a lot of research underway that could give patients and their families hope for years to come. You see changes in your body,” says Benisch, a sign of Alzheimer's disease.

Numerous trials are presently trying to become aware of the disorder as early as possible, earlier than reminiscence troubles surface, and begin remedies then. “That is wherein the transfer in studies has been made,” she says.

 

Infections:

 

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Common mind illnesses because of an contamination encompass meningitis and encephalitis. Meningitis is an contamination withinside the lining across the mind or spinal cord. Encephalitis is an contamination of the mind tissue. They frequently arise collectively and might reason neck stiffness, headache, fever and confusion. They may be deadly with out antiviral remedy.

 

Movement Disorders:

 

Parkinson's disorder, ataxias, tremor, dystonia, tics and Tourette syndrome are examples of motion issues that frequently development to a whole lack of function. They can cause tremors, gradual and stiff motion, lack of balance, speech impairment and problem walking. Parkinson's disorder is because of the lack of dopamine-generating mind cells.

 

The reasons of motion issues can variety from genetics to harm to the mind, backbone and peripheral nerves to stroke. Though no therapy is recognised, drug and bodily remedy remedies can assist relieve a few symptoms.

 

Neuro-muscular Diseases:

 

These issues assault peripheral nerves out of doors the mind and the muscular tissues they control. Amyotrophic lateral sclerosis, generally called ALS or Lou Gehrig's disorder, is the excellent recognised of those illnesses – having taken the lives of the baseball participant Gehrig and, extra recently, the scientist Stephen Hawking. It usually progresses swiftly and is in the long run deadly. Increasingly, cognitive troubles also are being diagnosed with ALS. And the revolutionary disorder can reason dementia in a few people. There are remedies to gradual ALS or assist with symptoms, however there is no therapy.

 

Another neuromuscular disorder is peripheral neuropathy (because of diabetes, chemotherapy or genetics), characterised with the aid of using pain, numbness and weakness, normally withinside the fingers or feet. Other neuromuscular illnesses encompass Guillain-Barre syndrome and CIDP (continual inflammatory demyelinating polyneuropathy), myasthenia gravis and muscular dystrophy.

 

For a few who have sustained nerve harm, like from peripheral neuropathy, nerve switch surgical treatment can be a remedy option. This surgical approach entails harvesting a regular functioning nerve from some other a part of the body, and implanting it in a place wherein the nerve isn't always functioning.

 

Seizure Disorders:

 

Epilepsy and different seizure issues have an effect on approximately 3.four million people, in line with the Centers for Disease Control and Prevention. Seizures are because of a disruption in mind activity, both due to illness, mind harm or different factors.

In addition to epilepsy, other seizure disorders include mesial temporal lobe epilepsy, post-stroke/post-concussion epilepsy, and genetically and pediatrically inherited epilepsy syndromes (Lenox-Gastaut, Dravet, West syndrome, and juvenile). myoclonia). They can be caused by genetic abnormalities, but often the cause is unknown. Treatments such as medication, surgery, and under special medical supervision the ketogenic diet help many patients control seizures associated with epilepsy. major cause of disability. An ischemic stroke occurs when blood flow to the brain is impaired by a blocked blood vessel. A hemorrhagic stroke occurs when a blood vessel in the brain ruptures, causing bleeding in the brain.

 

Symptoms of both include sudden confusion, weakness in the arms and legs, weakness especially on one side of the body, problems with vision and speech, and sudden emotional control problems.

 

In ischemic stroke, giving him a blood thinner called tPA within 3 hours of the stroke can dissolve blood clots and restore blood flow before extensive brain damage occurs. . “The brain has a hard time recovering after an injury,” says Benisch. “So we try to treat strokes as early as possible to restore oxygen and prevent long-term damage.” For hemorrhagic strokes, surgery is often necessary. Other vascular diseases that can limit blood supply to the brain include vasculitis and fibromuscular dysplasia.

 

Trauma:

 

The CDC reported in 2019 that there were approximately 2.87 million traumatic brain injuries in the United States in 2014.

 

Trauma, including concussion, can be mild or severe and can cause anything from mild headaches to confusion, unconsciousness, convulsions, and even death. Benisch emphasizes the importance of head protection for everyone. Wear a helmet when riding, etc. The brain does not cope well with repetitive head injuries.”

It can lead to memory loss, confusion, personality and behavior changes, balance and movement disorders, violence and suicide. Surgery and medication can treat some forms of brain trauma, and physical and behavioral rehabilitation can be effective as well. Trauma can also be life-changing. This can lead to significant loss of nerve function. For example, some people with spinal cord injuries become partially or completely paralyzed, says Michael Lawton, neurosurgeon, CEO and president of Dr. Phoenix's Barrow Institute of Neurology, who: says so. Some people lose function or sensation in their legs (paraplegia). Some people are completely paralyzed from the neck down and have no movement or sensation in all four limbs (tetraplegia).

 

In such cases, it may be difficult to restore functionality. However, research suggests that neurotransmission is a technique that may help some completely paralyzed patients regain arm and hand function.

 

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Assistive devices such as power wheelchairs help people with mobility problems.

 

Tumours:

 

Both benign and malignant tumours put pressure on or destroy brain tissue, causing physical problems related to affected areas of the brain. Tumors may originate in the brain or may spread to the brain from other organs.

 

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glioblastomas (the type that killed the late Arizona Senator. John McCain) occurs in the brain.

Astrocytoma. It arises from star-shaped cells called astrocytes.

Meningioma. These tumors form outside the brain in the meninges, the membranes that cover the brain and spinal cord, and are often grouped together with other brain tumors. , headaches, seizures, nausea and vomiting, vision or hearing problems, behavioral and cognitive problems, or movement and balance problems.

 

Tumors can also grow in the spine. "Tumors can actually arise in the spine, the bones...the spinal cord, the spinal nerves, or the spaces between them," said Daniel Ho, an associate professor of neurosurgery at the University of Florida. , said:

Hoh notes that the most common type of spinal tumor is one that develops in the spine after other types of cancer. So, for example, if a person has breast cancer, prostate cancer, or lung cancer, these tumors will spread from their original site to the spine. , or combinations thereof. New therapeutics, such as gene therapy and immunotherapy, which are still experimental, hold promise for future tumor treatment strategies.

 

Scoliosis:

 

In most cases, the cause of scoliosis or abnormal curvature of the spine is unknown. In other cases it is degenerative and can appear with age. In the latter case, the spine can become more curved over time, until the person collapses into a walker or cane.

 

Rarely, spinal tumors can cause scoliosis, Hoh stresses. When scoliosis is associated with another neurological or muscular condition such as cerebral palsy, spinal cord trauma, or spina bifida, it is known as neuromuscular scoliosis.

 

In most cases, scoliosis is mild and does not require medical intervention, often only x-ray monitoring.

 


Spina Bifida:

 

This birth defect - specifically the neural tube defect. The disease, called a disease, occurs serially: the most severe form is known as myelomeningocele.

And the center of that pancake is meant to twist over on itself right into a tube that ultimately will residence the spinal wire and the nerves,” explains Dr. Jason Blatt, an assistant professor of neurosurgery on the University of Florida.

“We attempt to do it earlier than that. But there may be no proof that ready as much as seventy two hours is dangerous for the kid,” he says  But inside seventy two hours of delivery we take the kid to surgical procedure and basically reconstruct the neural tube.”

 

But with present day treatment, that is a livable disorder for almost all of patients,” Blatt says.

However, if spina bifida is diagnosed during pregnancy, the woman is pre-referred to a child-care specialist to be advised of all options.

 

This nerve runs from just below the earlobe across the jaw and out to the side of the face. When it branches out, it reaches "all the different muscles that raise the eyebrows, frown, enable a smile, and give visual expression." It is not clear what caused the loss. However, experts believe a viral infection could play a role. Most people who develop the disease make a full recovery, whether they seek treatment or not. However, drugs such as corticosteroids may be prescribed to reduce inflammation. And other approaches such as physical therapy, such as facial massage and exercise, may be recommended to speed recovery.

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